Psychiatry Department - Oviedo University, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Asturias, Spain.
Ann Gen Psychiatry. 2011 Mar 14;10(1):7. doi: 10.1186/1744-859X-10-7.
We assessed the impact of generalised anxiety disorder (GAD) on disability and health-related quality of life in outpatients treated in psychiatric clinics via a secondary analysis conducted in 799 patients from a cross-sectional study of prevalence of GAD in psychiatric clinics.
Patients were allocated into two groups: follow-up (15.7%) and newly diagnosed patients (84.3%), and were administered the Hamilton Anxiety Scale (HAM-A), Clinical Global Impressions Scale (CGI), Sheehan Disability Scale (SDS), and 36-item short form structured quality of life questionnaire (SF-36) scales.
The newly diagnosed group showed higher significant intensity of anxiety (56.9% vs 43.0% (HAM-A >24)), psychiatrist's CGI Severity (CGI-S) scores (4.2 vs 3.7), and perceived stress according to SDS (5.7 vs 5.2). They also showed lower scores in mental health-related quality of life: 25.4 vs 30.8. Statistical differences by gender were not observed. GAD was shown to have a significant impact on patient quality of life and disability, with a substantial portion having persistent, out of control symptoms despite treatment.
These results suggest that there is still room for improvement in the medical management of patients with GAD treated in psychiatric clinics.
通过对精神科诊所广泛性焦虑障碍（GAD）患病率横断面研究中的 799 例患者进行二次分析，评估广泛性焦虑障碍对精神科诊所门诊患者残疾和健康相关生活质量的影响。
将患者分为两组：随访组（15.7%）和新诊断组（84.3%），并对其进行汉密尔顿焦虑量表（HAM-A）、临床总体印象量表（CGI）、Sheehan 残疾量表（SDS）和 36 项简明健康状况调查问卷（SF-36）评分。
新诊断组焦虑严重程度较高（56.9%比 43.0%（HAM-A＞24））、精神病医生 CGI 严重程度评分（CGI-S）较高（4.2 比 3.7）、SDS 感知压力较高（5.7 比 5.2）。他们的心理健康相关生活质量评分也较低：25.4 比 30.8。性别差异无统计学意义。GAD 显著影响患者的生活质量和残疾，尽管接受了治疗，但仍有相当一部分患者存在持续、失控的症状。
这些结果表明，精神科诊所治疗的 GAD 患者的医疗管理仍有改进空间。
