School of Sociology and Social Policy, University of Nottingham, Nottingham.
Br J Gen Pract. 2011 Jan;61(582):47-9. doi: 10.3399/bjgp11X548983.
Despite NICE guidance that should have limited it, antidepressant prescribing continues to increase. Research evidence suggests that much if not all of the observed efficacy should be attributed to complex non-specific effects rather than 'restoration of disturbed brain chemistry'. According to this view the uncertain benefits of antidepressants are unlikely to outweigh the risks, suggesting the need to explore other approaches to treatment.
尽管英国国家卫生与临床优化研究所（NICE）的指导意见本应限制其使用，但抗抑郁药的处方量仍在继续增加。研究证据表明，观察到的疗效在很大程度上（如果不是全部的话）归因于复杂的非特异性效应，而不是“恢复紊乱的大脑化学物质”。根据这种观点，抗抑郁药的不确定益处不太可能超过风险，这表明需要探索其他治疗方法。
