Grups J W, Bange F C
Department of Urology, University of Würzburg Medical School, FRG.
Urol Res. 1990;18(2):119-22. doi: 10.1007/BF00302471.
In previous investigations, it was demonstrated that interferons (IFN) have antiproliferative effects in human urothelial carcinomas. However, appreciable differences were found in the sensitivity of the individual tumors investigated. We therefore examined whether this might be due to a different receptor status of the cells. The IFN-sensitive cell lines RT4 and SD as well as the IFN-resistant cell line 639V were investigated with regard to their IFN receptor status. It was demonstrated that IFN receptors were present on the cell surface in all three urothelial carcinomas investigated. The number of IFN receptors calculated for the IFN-resistant cell line 639V was 4.661 per cell, whereas the IFN-sensitive cell line SD had 4.391 receptors and RT4 had 3.307 receptors. The IFN affinity of the three cell lines tested differed only slightly. Therefore IFN affinity is unlikely to account for their marked differences in IFN sensitivity.
在先前的研究中，已证明干扰素（IFN）对人尿路上皮癌具有抗增殖作用。然而，在所研究的各个肿瘤的敏感性方面发现了明显差异。因此，我们研究了这是否可能是由于细胞的受体状态不同所致。针对其IFN受体状态，研究了IFN敏感细胞系RT4和SD以及IFN耐药细胞系639V。结果表明，在所研究的所有三种尿路上皮癌中，细胞表面均存在IFN受体。计算得出，IFN耐药细胞系639V每个细胞的IFN受体数量为4.661个，而IFN敏感细胞系SD有4.391个受体，RT4有3.307个受体。所测试的三种细胞系的IFN亲和力仅略有差异。因此，IFN亲和力不太可能解释它们在IFN敏感性方面的显著差异。
