Department of Internal Medicine, Medical School of Ioannina, University of Ioannina, Greece.
Eur J Intern Med. 2011 Apr;22(2):191-4. doi: 10.1016/j.ejim.2010.11.010. Epub 2010 Dec 23.
To test the hypothesis that Helicobacter pylori infection is associated with a higher rate of documented cardiovascular disease (CVD) in subjects undergoing elective upper gastrointestinal endoscopy.
202 consecutive patients (median age 60 years, 101 men) were studied. H. pylori infection was established by a rapid urease test in a gastric tissue sample (CLO test) and by histological examination of gastric mucosa from the stomach antrum and body. CVD was documented by completion of the Rose questionnaire. The association of H. pylori infection with CVD was determined by multivariate logistic regression modelling after adjusting for potential confounding factors.
A total of 104 (51.5%) subjects were found H. pylori positive. Forty patients had a confirmed history of CVD. Multiple logistic regression analysis verified the strong associations of CVD with established risk factors of atherosclerotic disease but not with H. pylori infection.
Our findings suggest that there is no association of H. pylori infection with CVD. Eradication of H. pylori to prevent CVD is not warranted.
检验假设，即幽门螺杆菌（H. pylori）感染与接受择期上消化道内镜检查的患者中记录的心血管疾病（CVD）发生率较高相关。
研究了 202 例连续患者（中位年龄 60 岁，101 名男性）。通过胃组织样本（CLO 测试）中的快速尿素酶试验和胃窦和体部胃黏膜的组织学检查确定 H. pylori 感染。通过完成 Rose 问卷来记录 CVD。在调整了潜在混杂因素后，通过多变量逻辑回归模型确定 H. pylori 感染与 CVD 的关联。
共有 104 名（51.5%）患者 H. pylori 阳性。40 名患者有明确的 CVD 病史。多变量逻辑回归分析证实了 CVD 与动脉粥样硬化疾病的既定危险因素之间存在强烈关联，但与 H. pylori 感染无关。
我们的研究结果表明，H. pylori 感染与 CVD 之间没有关联。因此，没有理由通过根除 H. pylori 来预防 CVD。
