Department of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia.
Department of Medical Laboratory Sciences, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Front Endocrinol (Lausanne). 2024 Jul 16;15:1358411. doi: 10.3389/fendo.2024.1358411. eCollection 2024.
The prevalence of metabolic syndrome (MetS) in patients infected with , and the factors associated with it are not well understood. This study evaluates MetS and its associated factors among both H pylori-positive and H pylori-negative individuals in Northeast Ethiopia.
A cross-sectional study was conducted between 1 March 2022 to 30 May 2022. A semi-structured questionnaire was used to collect data on sociodemographic, behavioral, and clinical variables. A total of 228 subjects were randomly selected. Blood and stool samples were collected from each subject to measure fasting blood glucose and lipid profiles, and to identify infection. Data were entered into Epi. Data 3.1 and analyzed using SPSS version 25. Logistic regression analysis and the Mann-Whitney U-test were performed to determine associated factors and compare median and interquartile ranges.
Of the 228 participants, 114 were positive, and 114 were negative. Participants (50.9% female) ranged in age from 18 years to 63 years, with a median age of 31 (IQR, 22, 40) years. The overall prevalence of MetS among the participants was 23.2%. We found a statistically significant association between MetS and fasting blood glucose level (AOR, 15.965; 95% CI, 7.605-33.515, p<0.001). Furthermore, there was a statistically significant difference in the median serum levels of low-density lipoprotein cholesterol (p<0.001), triglycerides (p=0.036), systolic blood pressure (<0.001), and total cholesterol (p<0.001) between -positive and -negative participants.
MetS was prevalent among study participants. There was also a statistically significant association between fasting blood sugar and MetS. In addition, systolic blood pressure, total cholesterol, triglycerides, and low-density lipoprotein levels were significantly different between -positive and -negative individuals.
在感染 的患者中，代谢综合征（MetS）的流行率及其相关因素尚不清楚。本研究评估了东北埃塞俄比亚的 H pylori 阳性和 H pylori 阴性个体中的 MetS 及其相关因素。
2022 年 3 月 1 日至 5 月 30 日进行了一项横断面研究。使用半结构式问卷收集社会人口统计学、行为和临床变量的数据。从每个受试者中采集血液和粪便样本，以测量空腹血糖和血脂谱，并确定 是否感染。数据输入 Epi Data 3.1 并使用 SPSS 版本 25 进行分析。进行逻辑回归分析和 Mann-Whitney U 检验，以确定相关因素并比较中位数和四分位距。
在 228 名参与者中，114 名 阳性，114 名 阴性。参与者（50.9%为女性）年龄在 18 岁至 63 岁之间，中位数年龄为 31（IQR，22，40）岁。参与者中 MetS 的总体患病率为 23.2%。我们发现 MetS 与空腹血糖水平之间存在统计学显著关联（AOR，15.965；95%CI，7.605-33.515，p<0.001）。此外，-阳性和-阴性参与者之间血清低密度脂蛋白胆固醇（p<0.001）、甘油三酯（p=0.036）、收缩压（<0.001）和总胆固醇（p<0.001）的中位数水平存在统计学显著差异。
研究参与者中 MetS 患病率较高。空腹血糖与 MetS 之间也存在统计学显著关联。此外，-阳性和-阴性个体之间的收缩压、总胆固醇、甘油三酯和低密度脂蛋白水平存在显著差异。
