Therapeutics Research Centre, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.
Antimicrob Agents Chemother. 2011 Jun;55(6):3008-11. doi: 10.1128/AAC.00416-10. Epub 2011 Mar 14.
This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.
本研究旨在探讨胰腺炎如何影响灌注大鼠胰腺模型中抗生素的分布。在对照组动物和胰腺炎动物中，研究了四种抗生素的分布动力学。美罗培南和哌拉西林分布到细胞外间隙，其分布动力学不受胰腺炎影响。相比之下，在胰腺炎动物的胰腺细胞中，环丙沙星的摄取减少，克林霉素的分布减少。
