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前沿：IL-17+γδ T 细胞增强了致结肠炎 Th17 CD4 T 细胞的产生。

Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.

机构信息

Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

出版信息

J Immunol. 2011 Apr 15;186(8):4546-50. doi: 10.4049/jimmunol.1004021. Epub 2011 Mar 14.

DOI:10.4049/jimmunol.1004021
PMID:21402889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3200541/
Abstract

Th 17 cells have been implicated in the pathogenesis of colitis; however, a cellular mechanism by which colitogenic Th17 immunity arises in vivo remains unclear. In this study, we report that a subset of IL-17(+) γδ T cells plays a crucial role in enhancing in vivo Th17 differentiation and T cell-mediated colitis. TCRβ(-/-) mice were highly susceptible to T cell-mediated colitis, whereas TCRβδ(-/-) mice were resistant to the disease. Importantly, cotransfer of IL-17(+) but not of IL-17(-) γδ T cells with CD4 T cells was sufficient to enhance Th17 differentiation and induce full-blown colitis in TCRβδ(-/-) recipients. Collectively, our results provide a novel function of IL-17(+) γδ T cell subsets in supporting in vivo Th17 differentiation and possibly in fostering the development of intestinal inflammation.

摘要

Th17 细胞被认为与结肠炎的发病机制有关；然而，体内致结肠炎的 Th17 免疫产生的细胞机制仍不清楚。在这项研究中，我们报告说，IL-17(+)γδ T 细胞的一个亚群在增强体内 Th17 分化和 T 细胞介导的结肠炎中起着关键作用。TCRβ(-/-) 小鼠对 T 细胞介导的结肠炎高度敏感，而 TCRβδ(-/-) 小鼠则对该疾病具有抗性。重要的是，与 CD4 T 细胞共转移 IL-17(+)但不是 IL-17(-)γδ T 细胞足以增强 Th17 分化并在 TCRβδ(-/-)受者中诱导完全性结肠炎。总之，我们的结果提供了 IL-17(+)γδ T 细胞亚群在支持体内 Th17 分化和可能促进肠道炎症发展中的新功能。

相似文献

[1]
Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.

J Immunol. 2011-3-14

[2]
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[3]
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[4]
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[5]
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Eur J Immunol. 2012-10-17

[6]
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Gastroenterology. 2011-3-17

[7]
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[8]
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[9]
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[10]
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[5]
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[6]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation.

J Immunol. 2010-10-18

[2]
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.

Immunity. 2010-9-9

[3]
Innate IL-17-producing cells: the sentinels of the immune system.

Nat Rev Immunol. 2010-6-18

[4]
E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.

Immunity. 2010-4-15

[5]
Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells.

Invest Ophthalmol Vis Sci. 2010-4-7

[6]
Differentiation of effector CD4 T cell populations (*).

Annu Rev Immunol. 2010

[7]
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.

J Immunol. 2010-1-8

[8]
Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease.

World J Gastroenterol. 2009-12-14

[9]
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.

Proc Natl Acad Sci U S A. 2009-11-17

[10]
CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells.

Eur J Immunol. 2009-12

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