McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.
Department of Medicine, McMaster University, Hamilton, ON, Canada.
Front Immunol. 2022 Apr 14;13:861444. doi: 10.3389/fimmu.2022.861444. eCollection 2022.
Interleukin-17 (IL-17A) is a cytokine involved in a complex array of both protective and detrimental processes. Although early biological studies focused on the pro-inflammatory function of IL-17 in the context of autoimmune and inflammatory disorders, it has become increasingly evident that the roles of IL-17 are far more nuanced. Recent work has demonstrated that the functions of IL-17 are highly context- and tissue-dependent, and there is a fine balance between the pathogenic and protective functions of IL-17. This is especially evident in mucosal tissues such as the female reproductive tract, where IL-17 has been shown to play an important role in the immune response generated during fungal, bacterial and viral infections associated with protection, but also with inflammation. In this review, we discuss the evolving landscape of IL-17 biology within the context of the vaginal mucosa, focusing on key findings that highlight the importance of this cytokine in genital mucosal immunity.
白细胞介素-17（IL-17A）是一种细胞因子，参与多种保护和有害过程。尽管早期的生物学研究集中在白细胞介素-17 在自身免疫和炎症性疾病中的促炎功能，但越来越明显的是，白细胞介素-17 的作用远不止于此。最近的研究表明，白细胞介素-17 的功能高度依赖于上下文和组织，并且白细胞介素-17 的致病和保护功能之间存在微妙的平衡。这在女性生殖道等黏膜组织中尤为明显，白细胞介素-17 在真菌、细菌和病毒感染引起的免疫反应中发挥重要作用，既能保护又能引起炎症。在这篇综述中，我们讨论了白细胞介素-17 生物学在阴道黏膜中的不断发展的情况，重点讨论了突出这种细胞因子在生殖道黏膜免疫中重要性的关键发现。
