[Dehydroepiandrosterone sulfate (DHEAS) concentration changes in clomiphene therapy?].

Plasma DHEAS levels were followed in 10 anovulatory patients, treated with 50 mg clomiphene citrate from the 5th to the 9th day of menstruation as well as 6 ovulatory women, who were taken as controls. A serum progesterone level of 13 nmol/l or more in the luteal phase was found in both, the treatment and the control group. This was considered to be a strong indication, that ovulation had occurred. A significant preovulatory increase in DHEAS levels was found neither in the treatment nor in the control group. A negative influence of DHEAS on the ripening of the follicles due to a single dose of 50 mg of clomiphene during 5 days of menstruation seems unlikely.