Clinical Professor of Neurological Surgery, University of California, Davis, CA, USA.
J Alzheimers Dis. 2011;25(2):209-12. doi: 10.3233/JAD-2011-101935.
It has been widely believed that decreased cerebral blood flow (CBF), known to occur in Alzheimer's disease (AD), is the result of neuronal degeneration that causes a decrease in the need for adequate CBF. There is new interest in the idea, however, that it is not neuronal degeneration that leads to decreased CBF to critical neurons, but it is the decrease in CBF which is the cause of the neuronal deterioration seen in AD patients. In order to increase CBF to the AD brain, an operation called omental transposition has been developed in which an intact elongated omental pedicle, when placed directly on the brain, provides additional CBF and other biological nutrients to the brain. It is understandable that AD patients are awaiting a method to control their disease, but this may take years to become available. Placing the omentum on the AD brain has demonstrated increased CBF which may be the reason that several studies have shown that omental transposition to the brain can improve the cognitive ability of AD patients who have undergone the operation. What is needed is a prospective controlled study that could scientifically establish the benefit of the procedure.
人们普遍认为，大脑血流量（CBF）减少，这在阿尔茨海默病（AD）中很常见，是神经元退化导致对足够的 CBF 需求减少的结果。然而，人们对这样一种观点产生了新的兴趣，即导致关键神经元 CBF 减少的不是神经元退化，而是 CBF 的减少导致了 AD 患者大脑中神经元恶化。为了增加 AD 大脑的 CBF，开发了一种名为网膜转移的手术，其中完整的细长网膜蒂直接放置在大脑上，为大脑提供额外的 CBF 和其他生物营养物质。可以理解的是，AD 患者正在等待一种控制疾病的方法，但这可能需要数年时间才能实现。将网膜放置在 AD 大脑上已证明可以增加 CBF，这可能是几项研究表明网膜转移到大脑可以改善接受手术的 AD 患者认知能力的原因。目前需要的是一项前瞻性对照研究，可以从科学上确定该手术的益处。
