阿尔茨海默病：关键神经元内元素脑血流减少是病因。
Alzheimer's Disease: A Decreased Cerebral Blood Flow to Critical Intraneuronal Elements Is the Cause.
机构信息
Department of Neurosurgery (Retired), University of California, Davis, Sacramento, CA, USA.
出版信息
J Alzheimers Dis. 2022;85(4):1419-1422. doi: 10.3233/JAD-215479.
Abstract
Normally, an adequate cerebral blood flow arrives at individual cerebral neurons in which the blood flow augments activity of intraneuronal mitochondria, which is the source of intraneuronal ATP, the energy source of cerebral neurons. With a decrease in cerebral blood flow that can occur as a function of normal aging phenomena, less blood results in decreased mitochondria, decreased ATP, and a decrease in neuronal activity, which can eventually lead to Alzheimer's disease. It has been found that placement of the omentum directly on an Alzheimer's disease brain can lead to improved cognitive function.
摘要
通常情况下，充足的脑血流会到达单个脑细胞，使脑细胞内的线粒体活动增强，而线粒体是脑细胞内 ATP 的来源，也是脑细胞的能量来源。随着正常衰老现象的发生，脑血流量减少，导致线粒体减少、ATP 减少和神经元活动减少，最终可能导致阿尔茨海默病。现已发现，将大网膜直接置于阿尔茨海默病大脑上，可以改善认知功能。
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