Hata Akito, Katakami Nobuyuki, Masuda Yoshio, Nanjo Shigeki, Otsuka Kyoko, Kaji Reiko, Fujita Shiro, Iwamori Shigeo, Mifune Yuka, Orita Hiromi, Fukae Michiyo, Yamatani Toshiyuki
Division of Integrated Oncology, Institute of Biomedical Research and Innovation, Japan.
Gan To Kagaku Ryoho. 2011 Mar;38(3):415-8.
The administration of opioids to outpatients with cancer pain can be difficult because the constant dose modification and treatments of side effects involved are occasionally impossible. Therefore, more effective and safer drugs with better patients compliance are needed to complete a successful opioid introduction. Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence. Further more, compliance can be improved because the drug is a patch,administered transdermally.
Between July 2008 and December 2009, we investigated the safety and analgesic effect of a fentanyl patch (2.1 mg) as a direct opioid introduction for 36 outpatients with cancer pain without titrations of other opioids.
Side effects of constipation, nausea, somnolence, and dizziness were observed in 17 (47%), 6 (17%), 4 (11%), and 3 (8%) patients, respectively, and no respiratory suppression was observed. Regarding the analgesic effect, 23 (64%) patients reported improvement on pain scales one week after the initiation of the fentanyl patch.
Opioid introduction to opioid-naÏve outpatients with cancer pain using the low-dose fentanyl patch (2.1 mg) may be effective.
给癌症疼痛门诊患者使用阿片类药物可能会有困难，因为持续调整剂量以及处理相关副作用有时是不可能的。因此，需要更有效、更安全且患者依从性更好的药物来成功引入阿片类药物。与其他阿片类药物相比，低剂量芬太尼被认为会产生较轻微的副作用，如恶心、便秘和嗜睡。此外，由于该药物是透皮给药的贴片，所以可以提高依从性。
在2008年7月至2009年12月期间，我们调查了芬太尼贴片（2.1毫克）作为直接引入阿片类药物用于36例未滴定其他阿片类药物的癌症疼痛门诊患者的安全性和镇痛效果。
分别有17例（47%）、6例（17%）、4例（11%）和3例（8%）患者出现便秘、恶心、嗜睡和头晕等副作用，未观察到呼吸抑制现象。关于镇痛效果，23例（64%）患者在开始使用芬太尼贴片一周后报告疼痛程度有所改善。
使用低剂量芬太尼贴片（2.1毫克）向未使用过阿片类药物的癌症疼痛门诊患者引入阿片类药物可能是有效的。
