Tsuda Mumeko C, Yamaguchi Naoko, Ogawa Sonoko
Laboratory of Behavioral Neuroendocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Neuroreport. 2011 Apr 20;22(6):259-63. doi: 10.1097/WNR.0b013e328344495a.
To investigate the effects of early life stress on the development of social behaviors in male mice, we examined behavioral responses toward same sex stimulus mice in the social investigation test and aggressive behaviors in peripubertal male mice exposed to maternal separation (MS) during the first 2 weeks of life. MS suppressed aggressive behaviors from 5-9 weeks of age, but had no effect on social investigative behaviors in the social investigation test. Investigation of neuroendocrine bases of behavioral effects of MS showed that MS reduced plasma testosterone levels and decreased arginine vasopressin and increased oxytocin immunoreactivity in the paraventricular nucleus of peripubertal males. These results collectively suggest that early life stress disrupts the development of male aggressive behaviors and associated neuroendocrine systems.
为了研究早期生活应激对雄性小鼠社会行为发育的影响，我们在社会调查测试中检测了雄性小鼠对同性刺激小鼠的行为反应，并观察了在出生后前两周经历母婴分离（MS）的青春期雄性小鼠的攻击行为。母婴分离抑制了5至9周龄小鼠的攻击行为，但对社会调查测试中的社会探究行为没有影响。对母婴分离行为效应的神经内分泌基础的研究表明，母婴分离降低了青春期雄性小鼠的血浆睾酮水平，减少了精氨酸加压素，并增加了室旁核中催产素的免疫反应性。这些结果共同表明，早期生活应激会扰乱雄性攻击行为及相关神经内分泌系统的发育。
