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异贝壳杉烯及其衍生物的合成与生物活性。

Allobetulin and its derivatives: synthesis and biological activity.

机构信息

Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, 3-3001 Leuven, Belgium.

出版信息

Molecules. 2011 Mar 14;16(3):2443-66. doi: 10.3390/molecules16032443.

DOI:10.3390/molecules16032443
PMID:21403601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6259842/
Abstract

This review covers the chemistry of allobetulin analogs, including their formation by rearrangement from betulin derivatives, their further derivatisation, their fusion with heterocyclic rings, and any further rearrangements of allobetulin compounds including ring opening, ring contraction and ring expansion reactions. In the last part, the most important biological activities of allobetulin derivatives are listed. One hundred and fifteen references are cited and the relevant literature is covered, starting in 1922 up to the end of 2010.

摘要

本文综述了别他灵芝醇类似物的化学性质,包括其通过别他灵芝烷衍生物重排生成,进一步衍生化,与杂环环系融合,以及包括开环、缩环和扩环反应在内的别他灵芝醇化合物的任何进一步重排。最后一部分列出了别他灵芝醇衍生物的最重要的生物活性。引用了 115 篇参考文献,涵盖了 1922 年至 2010 年底的相关文献。

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