[从别桦木醇合成新的齐墩果-18(19)-烯衍生物]

[Synthesis of new olean-18(19)-ene derivatives from allobetulin].

作者信息

Kazakova O B, Khusnutdinova É F, Tolstikov G A, Suponitskiĭ K Iu

出版信息

Bioorg Khim. 2010 Jul-Aug;36(4):552-5. doi: 10.1134/s1068162010040102.

DOI:10.1134/s1068162010040102

PMID:20823924

Abstract

Effective synthesis of new olean-18(19)-ene triterpenoids based on interaction of allobetulin or its acetate with phosphorous oxychloride in pyridine under reflux is described. The structures of the synthesized 17-chloromethyl-oleane-18(19)-enes have been established with the help of NMR-spectroscopy and X-Ray analysis.

摘要

描述了基于去甲白桦脂醇或其乙酸酯与三氯氧磷在吡啶中回流时的相互作用有效合成新的齐墩果-18(19)-烯三萜类化合物的方法。借助核磁共振光谱和X射线分析确定了合成的17-氯甲基-齐墩果-18(19)-烯的结构。