Division of Pediatric Nephrology, University of California, San Diego, La Jolla, California 92093-0634, USA.
Kidney Int. 2011 Apr;79(7):697-9. doi: 10.1038/ki.2010.520.
Ghrelin is involved in the pathogenesis of protein-energy wasting (PEW), inflammation, and cardiovascular complications in end-stage renal disease (ESRD). Plasma ghrelin may prove to be a powerful biomarker of mortality in ESRD but should be considered in the context of assay specificity, other weight-regulating hormones, nutritional status, systemic inflammation, and cardiovascular risk factors. ESRD patients with PEW, systemic inflammation, and low ghrelin and high leptin concentrations have the highest mortality risk and may benefit the most from ghrelin therapy.
胃饥饿素参与终末期肾病（ESRD）中蛋白质-能量消耗（PEW）、炎症和心血管并发症的发病机制。血浆胃饥饿素可能被证明是 ESRD 患者死亡的有力生物标志物，但应考虑到检测特异性、其他调节体重的激素、营养状况、全身炎症和心血管危险因素。患有 PEW、全身炎症以及低胃饥饿素和高瘦素浓度的 ESRD 患者具有最高的死亡风险，可能最受益于胃饥饿素治疗。
