Jenike M A, Baer L, Greist J H
Harvard Medical School, Belmont, Massachusetts, Boston.
J Clin Psychopharmacol. 1990 Apr;10(2):122-4. doi: 10.1097/00004714-199004000-00008.
Since it will be some time until data will be available comparing clomipramine and fluoxetine for the treatment of patients with obsessive-compulsive disorder (OCD), a meta-analysis of previous studies was performed in an attempt to gain some information about comparable efficacy and side effects of these two commonly used agents. In 31 OCD patients receiving clomipramine in a controlled trial and 72 OCD patients receiving fluoxetine openly, both drugs appeared effective, with clomipramine having a somewhat larger effect than fluoxetine. Different side effect profiles may have a bearing on patient selection.
由于要获得比较氯米帕明和氟西汀治疗强迫症（OCD）患者的数据还需要一段时间，因此对先前的研究进行了荟萃分析，试图获取有关这两种常用药物的疗效和副作用的可比信息。在一项对照试验中，31名接受氯米帕明治疗的强迫症患者和72名接受氟西汀开放治疗的强迫症患者中，两种药物均显示有效，氯米帕明的疗效略大于氟西汀。不同的副作用特征可能会影响患者的选择。
