抗抑郁治疗与因抑郁入院的双相情感障碍患者躁狂发作的关系。

Antidepressant treatment and the occurrence of mania in bipolar patients admitted for depression.

作者信息

Solomon R L, Rich C L, Darko D F

机构信息

Department of Psychiatry, State University of New York, Stony Brook.

出版信息

J Affect Disord. 1990 Apr;18(4):253-7. doi: 10.1016/0165-0327(90)90076-k.

DOI:10.1016/0165-0327(90)90076-k

PMID:2140377

Abstract

We examined the records of 33 patients who had 70 inpatient admissions with a diagnosis of bipolar affective disorder, depressed. During 14 of these admissions, a switch occurred from depression into mania. We compared the treatment patients were on at the time of their switch to treatment during the 56 admissions where there was no switch. We conclude that clinicians must be prepared for depressed bipolar patients to switch to mania regardless of treatment status.

摘要

我们检查了33例被诊断为双相情感障碍抑郁发作的患者的记录，这些患者共住院70次。在其中14次住院期间，患者从抑郁发作转变为躁狂发作。我们比较了这些患者在发作转变时所接受的治疗与另外56次未发生发作转变的住院期间所接受的治疗。我们得出结论，临床医生必须为抑郁发作的双相情感障碍患者转变为躁狂发作做好准备，无论其治疗状态如何。