Li Yongqing, Alam Hasan B
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, 165 Cambridge Street, Suite 810, Boston, MA 02114, USA.
J Biomed Biotechnol. 2011;2011:523481. doi: 10.1155/2011/523481. Epub 2011 Feb 15.
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular activities. In this paper we review and discuss intriguing recent developments in the use of histone deacetylase inhibitors (HDACIs) to combat some critical conditions in an animal model of hemorrhagic and septic shock. HDACIs have neuroprotective, cardioprotective, renal-protective, and anti-inflammatory properties; survival improvements have been significantly shown in these models. We discuss the targets and mechanisms underlying these effects of HDACIs and comment on the potential new clinical applications for these agents in the future. This paper highlights the emerging roles of HDACIs as acetylation modulators in models of hemorrhagic and septic shock and explains some contradictions encountered in previous studies.
组蛋白去乙酰化酶（HDACs）在组蛋白和非组蛋白的蛋白质乙酰化稳态以及调节基本细胞活动中发挥关键作用。在本文中，我们回顾并讨论了在出血性和脓毒性休克动物模型中使用组蛋白去乙酰化酶抑制剂（HDACIs）对抗一些危急病症方面最近的有趣进展。HDACIs具有神经保护、心脏保护、肾脏保护和抗炎特性；在这些模型中已显著显示出能提高生存率。我们讨论了HDACIs这些作用的靶点和机制，并对这些药物未来潜在的新临床应用进行了评论。本文强调了HDACIs作为出血性和脓毒性休克模型中乙酰化调节剂的新作用，并解释了先前研究中遇到的一些矛盾之处。
