Department of Nephrology and Renal Transplantation, Centro Hospitalar Lisboa Norte, EPE, Hospital de Santa Maria, Avenida Professor Egas Moniz, 1649-035 Lisboa, Portugal.
Cardiol Res Pract. 2011 Feb 20;2011:747861. doi: 10.4061/2011/747861.
The metabolic syndrome (MS) and chronic kidney disease (CKD) have both become global public health problems, with increasing social and economic impact due to their high prevalence and remarkable impact on morbidity and mortality. The causality between MS and CKD, and its clinical implications, still does remain not completely understood. Moreover, prophylactic and therapeutic interventions do need to be properly investigated in this field. Herein, we critically review the existing clinical evidence that associates MS with renal disease and cardiovascular disease, as well as the associated pathophysiologic mechanisms and actual treatment options.
代谢综合征（MS）和慢性肾脏病（CKD）均已成为全球性公共卫生问题，由于其高患病率以及对发病率和死亡率的显著影响，其社会和经济影响日益增加。MS 与 CKD 之间的因果关系及其临床意义仍不完全清楚。此外，还需要在该领域对预防性和治疗性干预措施进行适当的研究。在此，我们批判性地回顾了将 MS 与肾脏疾病和心血管疾病相关联的现有临床证据，以及相关的病理生理机制和实际治疗选择。
