Section of Neonatology, Department of Surgical and Medical Critical Care, Careggi University Hospital of Florence, Viale Morgagni 85, Florence, Italy.
Am J Perinatol. 2011 Aug;28(7):551-6. doi: 10.1055/s-0031-1274503. Epub 2011 Mar 14.
The possible correlation between the mean platelet volume (MPV) and the occurrence of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH) in a cohort of preterm infants was assessed. We studied infants with gestational age <30 weeks. Enrolled infants were divided into BPD and no-BPD groups and IVH and no-IVH groups. MPV was evaluated at birth and at 24 to 48 hours of life. MPV measured at birth was similar in BPD and no-BPD groups, but at 24 to 48 hours of life was higher in the BPD than in the no-BPD group (11.1 ± 0.9 versus 10.8 ± 0.9 fL, P = 0.033) and multivariate analysis demonstrated that MPV >11 fL increases (relative risk 1.40, 95% confidence interval 1.08 to 1.80) the risk of developing BPD. MPV was similar in infants with or without IVH. We concluded that high MPV in the first days of life is a risk factor for the development of BPD in extremely preterm infants. This might be because high MPV could favor inflammatory and oxidative lung damage. On the contrary, our data indicate that MPV is not associated with the development of IVH in our population.
我们评估了血小板平均体积（MPV）与早产儿支气管肺发育不良（BPD）和脑室内出血（IVH）发生之间的可能相关性。我们研究了胎龄<30 周的婴儿。纳入的婴儿分为 BPD 组和非 BPD 组以及 IVH 组和非 IVH 组。在出生时和出生后 24 至 48 小时评估 MPV。BPD 组和非 BPD 组出生时的 MPV 相似，但在出生后 24 至 48 小时，BPD 组的 MPV 高于非 BPD 组（11.1±0.9 比 10.8±0.9 fL，P=0.033），多变量分析表明，MPV>11 fL 增加（相对风险 1.40，95%置信区间 1.08 至 1.80）BPD 发生的风险。有无 IVH 的婴儿的 MPV 相似。我们得出结论，生命最初几天的高 MPV 是极早产儿发生 BPD 的危险因素。这可能是因为高 MPV 可能有利于炎症和氧化肺损伤。相反，我们的数据表明，在我们的人群中，MPV 与 IVH 的发生无关。
