Neonatology Unit, Department of Pediatrics, School of Medicine, Gülhane Military Academy of Medicine, Ankara, Turkey.
Eur Rev Med Pharmacol Sci. 2013 Jan;17(1):134-7.
Mean platelet volume [MPV] is an important predictor for many diseases and larger platelets are more reactive and associated with shortened bleeding time. Although elevated MPV values are related to respiratory distress syndrome [RDS] in neonates, there are, to our knowledge, no data investigating the relationship between MPV and other diseases of preterm infants.
To assess the correlation between MPV and the occurrence of various morbidities of prematurity such as necrotizing enterocolitis [NEC], bronchopulmonary dysplasia [BPD], sepsis, retinopathy of prematurity [ROP], and intraventricular hemorrhage [IVH] in a cohort of very preterm infants.
We studied infants with a gestational age of < 34 weeks and a birth weight of < 1500 g admitted to a third level Neonatal Intensive Care Unit. Enrolled infants were divided into NEC and non-NEC, sepsis and non-sepsis, ROP and non-ROP, BPD and non-BPD and IVH and non-IVH groups. MPV was evaluated at birth [cord blood] and repeated at 48-72 hours of life.
Two hundred and seventy two infants were studied. MPV measured at birth was similar between sepsis and non-sepsis, and ROP and non-ROP groups. MPV values were higher in infants with BPD [9.08±1.3 fl], IVH [8.4±1.1fl] and NEC [8.6±0.7 f] when compared to the control group [7.6±0.6 fl] in the first day of life.
High MPV in the first hours of life may reflect the presence of a risk factor for the development of NEC, BPD and IVH in extremely preterm infants. This might be associated with inflammatory and oxidative process. However, our data indicate that higher MPV values are not associated with the development of sepsis or ROP in this study population.
平均血小板体积（MPV）是许多疾病的重要预测指标，较大的血小板更具反应性，与出血时间缩短有关。虽然新生儿呼吸窘迫综合征（RDS）中MPV 值升高，但据我们所知，尚无研究血小板体积与早产儿其他疾病之间关系的数据。
评估血小板体积与极低出生体重儿多种早产并发症（如坏死性小肠结肠炎[NEC]、支气管肺发育不良[BPD]、败血症、早产儿视网膜病变[ROP]和脑室出血[IVH]）发生的相关性。
我们研究了胎龄<34 周且出生体重<1500 g 的入住三级新生儿重症监护病房的婴儿。纳入的婴儿分为 NEC 和非 NEC、败血症和非败血症、ROP 和非 ROP、BPD 和非 BPD 以及 IVH 和非 IVH 组。出生时（脐血）评估血小板体积，生命第 48-72 小时重复测量。
共研究了 272 名婴儿。出生时血小板体积在败血症和非败血症组以及 ROP 和非 ROP 组之间相似。与对照组（第 1 天 7.6±0.6fl）相比，BPD [9.08±1.3fl]、IVH [8.4±1.1fl]和 NEC [8.6±0.7fl]患儿的血小板体积值更高。
生命最初几小时内血小板体积升高可能反映了极高早产儿发生 NEC、BPD 和 IVH 的危险因素。这可能与炎症和氧化过程有关。然而，我们的数据表明，在本研究人群中，较高的血小板体积值与败血症或 ROP 的发生无关。
