Marak G E, Sery T W, Gregerson D, Donoso L A, Rao N A
Center for Sight Georgetown II., Washington, D.C.
Ophthalmic Res. 1990;22(2):111-6. doi: 10.1159/000267009.
The hexose monophosphate shunt inhibitor 6-aminonicotinamide was observed to have an anti-inflammatory effect in the treatment of experimental uveitis. The electrons required for the reduction of molecular oxygen to superoxide radicals are generated by the pentose phosphate pathway in acute inflammatory cells. The inhibition of superoxide production is discussed as one of the potential antiphlogistic mechanisms.
已观察到己糖磷酸支路抑制剂6-氨基烟酰胺在治疗实验性葡萄膜炎方面具有抗炎作用。在急性炎症细胞中，将分子氧还原为超氧自由基所需的电子由磷酸戊糖途径产生。超氧化物生成的抑制被认为是潜在的抗炎机制之一。
