急性眼部炎症的药理学调节。I. 腺苷。
Pharmacologic modulation of acute ocular inflammation. I. Adenosine.
作者信息
Marak G E, de Kozak Y, Faure J P, Rao N A, Romero J L, Ward P A, Till G O
机构信息
Center for Sight, Georgetown University, Washington, D.C.
出版信息
Ophthalmic Res. 1988;20(4):220-6. doi: 10.1159/000266646.
PMID:3263602
Abstract
Modulation of signal transduction at the surface of inflammatory cells appears to influence acute inflammation. Adenosine, a well-known chemical messenger, inhibits the production of superoxide by stimulated neutrophils. In experimental allergic uveitis induced by sensitization with retinal 's' antigen, treatment with adenosine produced a marked reduction in the expected inflammation.
摘要
炎症细胞表面信号转导的调节似乎会影响急性炎症。腺苷是一种著名的化学信使，可抑制受刺激的中性粒细胞产生超氧化物。在用视网膜 “s” 抗原致敏诱导的实验性过敏性葡萄膜炎中，腺苷治疗使预期的炎症明显减轻。
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