Wong E F, Koh L W, Huang M H, Wong N L
Department of Medicine, University of British Columbia, Vancouver, Canada.
Asia Oceania J Obstet Gynaecol. 1990 Mar;16(1):79-83. doi: 10.1111/j.1447-0756.1990.tb00219.x.
Atrial natriuretic peptide (ANP), a new cardiac hormone, has potent natriuretic, diuretic and vaso-relaxant properties in animals and humans. Plasma ANP levels increased in response to volume expansion, atrial distension or postural change. The present investigation was designed to examine the effect of labour on plasma ANP in normotensive pregnant women. The results show that plasma ANP in pregnant women (n = 9) increased significantly in active phase of first stage of labour from 19.5 +/- 4.6 pg/ml to 74.5 +/- 15.1 pg/ml. The magnitude of the increase in ANP levels in active phase varied among the patients. During and after delivery, plasma ANP decreased in all instances towards control level. The cause for the increase in plasma ANP levels in the active phase remains to be determined.
心房利钠肽（ANP）是一种新的心脏激素，在动物和人类中具有强大的利钠、利尿和血管舒张特性。血浆ANP水平会因容量扩张、心房扩张或体位改变而升高。本研究旨在探讨分娩对血压正常的孕妇血浆ANP的影响。结果显示，9名孕妇在第一产程活跃期时血浆ANP显著升高，从19.5±4.6皮克/毫升升至74.5±15.1皮克/毫升。活跃期ANP水平升高的幅度在患者之间有所不同。在分娩期间及之后，所有情况下血浆ANP均降至对照水平。活跃期血浆ANP水平升高的原因尚待确定。
