Steegers E A, Hein P R, Tan A C, Groeneveld E A, Jongsma H W, Benraad T J
Department of Obstetrics and Gynecology, St. Radboud Hospital, University of Nijmegen, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 1987 Nov;26(3):213-7. doi: 10.1016/0028-2243(87)90070-0.
Plasma concentrations of atrial natriuretic peptide (ANP) were determined ante- and post-partum in 7 healthy primiparous women. ANP was measured at weekly intervals from the 35th week of pregnancy onwards and throughout the puerperium up to the sixth week post-partum. In all seven patients the mean of the ANP values during the first four days post-partum was higher than in late pregnancy. The mean ANP level from the 6th day up to the 42nd day showed a marked decrease compared with the first four days after birth, which, however, did not differ significantly from the mean plasma concentration in late pregnancy. In conclusion, ANP is markedly elevated during the first few days post-partum compared with plasma levels in the normal late pregnancy and the subsequent puerperium.
对7名健康初产妇在产前和产后测定了血浆心房利钠肽（ANP）浓度。从妊娠第35周起，每周测定一次ANP，直至产褥期结束，即产后第六周。在所有7名患者中，产后头四天的ANP值平均值高于妊娠晚期。与出生后的头四天相比，从第6天到第42天的ANP平均水平显著下降，然而，这与妊娠晚期的平均血浆浓度没有显著差异。总之，与正常妊娠晚期和随后的产褥期血浆水平相比，产后头几天ANP显著升高。
