Part Fibre Toxicol. 2011 Mar 15;8:12; author reply 12. doi: 10.1186/1743-8977-8-12.
Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.
吸入细颗粒物(<2.5μm;细 PM)已被证明会增加心血管事件的风险。在这封信中,我们重新评估了组织因子(TF)抗原的作用,并总结了其他研究中细 PM 对人类和啮齿动物的凝血蛋白的变化。通过考虑包括我们在内的所有研究,我们得出结论,通过测量凝血酶生成等容量测定法或 TF 活性的定量来监测整体凝血状态,比测定单个凝血蛋白(如 TF 抗原)更适合,以便更好地评估细 PM 的全身性促血栓形成作用。