Cancers and Populations, ERI3 INSERM, Faculty of Medicine, Caen University Hospital, Caen, France.
Occup Environ Med. 2011 Nov;68(11):832-6. doi: 10.1136/oem.2010.059790. Epub 2011 Mar 15.
The aim of our study was to analyse the dose-response relationship between occupational asbestos exposure and risk of cancer.
Our study was a retrospective morbidity study based on 2024 subjects occupationally exposed to asbestos, conducted over the period 1 January 1978 to 31 December 2004. Analysis of the dose-response relationship between occupational asbestos exposure, as a time-dependant variable, and risk of cancer was performed using a Cox model. In order to account for the effect of latency, we conducted the analysis with a lag of 10 years.
285 cases of cancers were observed in our cohort. The relative risk of pleuro-peritoneal mesothelioma, lung cancer and colorectal cancer associated with asbestos exposure, adjusted for age as a time-dependant variable and for sex, was correlated with exposure intensity (or average exposure level, AEL). The risk of cancer, whatever the anatomical site, did not increase with the duration of exposure to asbestos.
While confirming the established relationship between asbestos exposure and pleuropulmonary and peritoneal cancers, this study also suggests a causal relationship between asbestos exposure and colorectal cancer.
我们研究的目的是分析职业性石棉暴露与癌症风险之间的剂量-反应关系。
我们的研究是一项基于 2024 名职业性接触石棉的受试者的回顾性发病率研究，研究时间为 1978 年 1 月 1 日至 2004 年 12 月 31 日。使用 Cox 模型分析职业性石棉暴露（作为时间依赖变量）与癌症风险之间的剂量-反应关系。为了考虑潜伏期的影响，我们进行了 10 年潜伏期的分析。
在我们的队列中观察到 285 例癌症病例。调整年龄（作为时间依赖变量）和性别后，与石棉暴露相关的胸膜-腹膜间皮瘤、肺癌和结直肠癌的相对风险与暴露强度（或平均暴露水平，AEL）相关。无论解剖部位如何，癌症风险都不会随着接触石棉的时间延长而增加。
本研究证实了石棉暴露与胸膜肺部和腹膜癌症之间的既定关系，还提示了石棉暴露与结直肠癌之间的因果关系。
