Karbowski A, Matthiass H H
Klinik und Poliklinik für Allgemeine Orthopädie der Westfälischen Wilhelms-Universität Münster.
Z Orthop Ihre Grenzgeb. 1990 Mar-Apr;128(2):115-22. doi: 10.1055/s-2008-1039485.
Prostaglandins induce very probably the local intercellular communication and regulate the metabolism of bone and cartilage. They are supposed to be local mediators of mechanical stress, electric phenomena as well as of hormonal control mechanisms in cytobiologic and cytochemical reactions within the skeletal system. In-vitro prostaglandins act as potent bone and cartilage resorbing agents. In-vivo they also promote the synthesis of bone in a way that is not known as yet. Experimental investigations proved their influence on inflammatory processes, and, above all on the bone destruction in the pathogenesis of rheumatoid arthritis and osteomyelitis. It is the aim of the following review to elucidate the function and metabolism of prostaglandins with regard to their clinical importance and, particularly, to orthopaedic diseases.
前列腺素很可能诱导局部细胞间通讯，并调节骨骼和软骨的代谢。它们被认为是机械应力、电现象以及骨骼系统内细胞生物学和细胞化学反应中激素控制机制的局部介质。在体外，前列腺素是强效的骨骼和软骨吸收剂。在体内，它们还以一种尚不清楚的方式促进骨骼合成。实验研究证明了它们对炎症过程的影响，尤其是对类风湿性关节炎和骨髓炎发病机制中骨破坏的影响。以下综述的目的是阐明前列腺素的功能和代谢，及其临床重要性，特别是与骨科疾病的关系。
