肺动脉高压患者的血小板指标。
Platelet indices in patients with pulmonary arterial hypertension.
机构信息
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
出版信息
Clin Appl Thromb Hemost. 2011 Nov-Dec;17(6):E171-4. doi: 10.1177/1076029610394438. Epub 2011 Mar 14.
BACKGROUND
Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Vasoconstriction, remodeling, and thrombosis cause increased pulmonary vascular resistance and pressure. Previous studies have demonstrated that platelet activation occurs in patients with PAH. Our aim was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with PAH.
PATIENTS AND METHOD
The study group consisted of 22 patients with PAH. An age-, gender-, and body mass index-matched control group was composed of 25 healthy volunteers. All patients underwent physical examination, echocardiography, and diagnostic cardiac catheterization. We measured serum MPV values and platelet counts in patients with PAH and control participant.
RESULTS
MPV was significantly higher among the patients with PAH when compared with control group (8.68 ± 0.87 vs 8.02 ± 0.68 fl, respectively; P = .006).
CONCLUSION
We have shown that MPV was elevated in patients with PAH.
背景
肺动脉高压（PAH）是一种以肺动脉压力持续升高为特征的慢性进行性疾病。血管收缩、重塑和血栓形成导致肺血管阻力和压力增加。先前的研究表明，PAH 患者存在血小板活化。我们的目的是评估平均血小板体积（MPV），这是 PAH 患者血小板活化的一个指标。
患者和方法
研究组由 22 名 PAH 患者组成。年龄、性别和体重指数匹配的对照组由 25 名健康志愿者组成。所有患者均接受体格检查、超声心动图和诊断性心导管检查。我们测量了 PAH 患者和对照组参与者的血清 MPV 值和血小板计数。
结果
与对照组相比，PAH 患者的 MPV 显著升高（分别为 8.68±0.87 和 8.02±0.68 fl；P=0.006）。
结论
我们已经表明，PAH 患者的 MPV 升高。
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