Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey.
Clin Appl Thromb Hemost. 2011 Nov-Dec;17(6):E224-30. doi: 10.1177/1076029610397753. Epub 2011 Mar 14.
We aimed to determine plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels in women with previous gestational diabetes mellitus (GDM) and to evaluate the possible association of plasma TAFI with glucose intolerance and markers of subclinical atherosclerosis. This cross-sectional study was performed in 111 women with previous GDM and 60 controls. Glucose intolerance was evaluated. Homeostasis model assessment score was calculated. Circulating lipids, interleukin-6, matrix metalloproteinase-1, fibrinogen, plasminogen activator inhibitor-1, and TAFI antigen levels were assayed. Carotid intima media thickness (IMT) was measured. Women with previous GDM had increased levels of atherosclerosis markers and carotid IMT. On the other hand, plasma TAFI antigen levels were similar (P = .395). Thrombin-activatable fibrinolysis inhibitor was not associated with the indices of insulin resistance, glucose intolerance, markers of atherosclerosis, and carotid IMT. Our data demonstrated that plasma TAFI was not altered in women with previous GDM. TAFI was not associated with glucose intolerance and subclinical atherosclerosis.
我们旨在确定既往妊娠糖尿病（GDM）女性的血浆凝血酶激活的纤溶抑制物（TAFI）抗原水平，并评估血浆 TAFI 与葡萄糖耐量异常和亚临床动脉粥样硬化标志物之间的可能关联。这项横断面研究在 111 名既往 GDM 女性和 60 名对照者中进行。评估了葡萄糖耐量异常。计算了稳态模型评估评分。测定了循环脂质、白细胞介素-6、基质金属蛋白酶-1、纤维蛋白原、纤溶酶原激活物抑制剂-1 和 TAFI 抗原水平。测量了颈动脉内膜中层厚度（IMT）。既往 GDM 女性的动脉粥样硬化标志物和颈动脉 IMT 水平升高。另一方面，血浆 TAFI 抗原水平相似（P =.395）。凝血酶激活的纤溶抑制物与胰岛素抵抗指数、葡萄糖耐量异常、动脉粥样硬化标志物和颈动脉 IMT 无关。我们的数据表明，既往 GDM 女性的血浆 TAFI 没有改变。TAFI 与葡萄糖耐量异常和亚临床动脉粥样硬化无关。
