Department of Obstetrics and Gynecology, Fatih University Medical School, Ankara, Turkey.
Gynecol Endocrinol. 2013 Apr;29(4):327-30. doi: 10.3109/09513590.2010.501884. Epub 2013 Jan 18.
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase, which is synthesised in liver and activated by thrombin and the thrombin-thrombomodulin complex. TAFI suppresses fibrinolysis by removing carboxy-terminal lysine residues from partially degraded fibrin. In this study we aimed to assess the circulating levels of TAFI antigen, 'a fibrinolytic parameter' in women with gestational diabetes (GDM). Thirty-four pregnant women with GDM and 50 pregnant women with normal glucose tolerance were included in the study. Plasma TAFI antigen levels were significantly higher in pregnant women with GDM when compared with controls. Increased TAFI levels may contribute to the decreased fibrinolytic potency, causing a thrombophilic state. GDM is regarded as a specific form of diabetes, and it could in addition be a predictor of type 2 diabetes mellitus in the future and the risk of complications due to hypercoagulability increases in this disease. Increased TAFI levels may also have a role in increased risk of hypercoagulability.
凝血酶激活的纤溶抑制物（TAFI）是一种前羧肽酶，在肝脏中合成，并被凝血酶和凝血酶-血栓调节蛋白复合物激活。TAFI 通过从部分降解的纤维蛋白中去除羧基末端赖氨酸残基来抑制纤溶。在这项研究中，我们旨在评估患有妊娠期糖尿病（GDM）的女性的循环 TAFI 抗原水平，即“纤溶参数”。研究纳入了 34 名患有 GDM 的孕妇和 50 名血糖正常的孕妇。与对照组相比，患有 GDM 的孕妇的血浆 TAFI 抗原水平显著升高。升高的 TAFI 水平可能导致纤溶活性降低，从而导致血栓形成状态。GDM 被认为是一种特殊形式的糖尿病，它将来可能是 2 型糖尿病的预测因子，并且由于这种疾病的高凝状态，并发症的风险增加。升高的 TAFI 水平也可能与高凝风险增加有关。
