人类胎盘含有一种上皮散射蛋白。

Human placenta contains an epithelial scatter protein.

作者信息

Rosen E M, Meromsky L, Romero R, Setter E, Goldberg I

机构信息

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510.

出版信息

Biochem Biophys Res Commun. 1990 May 16;168(3):1082-8. doi: 10.1016/0006-291x(90)91140-n.

DOI:10.1016/0006-291x(90)91140-n

PMID:2140676

Abstract

Scatter factor (SF) is a protein produced by cultured fibroblasts which causes epithelia to "scatter" into isolated cells. We found significant scatter activity in vivo in second trimester (but not term) human amniotic fluid and in human placenta. Placental SF was purified 500,000-fold and identified as a protein with Mr 78 kd. Factor scattered Madin-Darby canine kidney and human squamous carcinoma cells at 15 pM. Amino acid sequences from tryptic peptides did not match any known protein. Human placental fibroblasts produced high titers of scatter activity. SF may be involved in development and may enhance carcinoma invasion.

摘要

分散因子（SF）是一种由培养的成纤维细胞产生的蛋白质，它可使上皮细胞“分散”成单个细胞。我们发现，在孕中期（而非足月时）的人羊水和人胎盘中存在显著的体内分散活性。胎盘SF被纯化了50万倍，并被鉴定为一种分子量为78kd的蛋白质。该因子在15pM时可使麦迪逊-达比犬肾细胞和人鳞状癌细胞分散。胰蛋白酶肽段的氨基酸序列与任何已知蛋白质均不匹配。人胎盘成纤维细胞产生高滴度的分散活性。SF可能参与发育过程，并可能增强癌侵袭。