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人类白细胞抗原 I 类抗原在妄想障碍中的作用。

Role of hla class-I antigens in delusional disorder.

机构信息

MONOJIT DEBNATH, Junior Research Fellow, Cellular Immunology Lab , Deptt. of Zoology, North Bengal University, Siliguri, West Bengal.

出版信息

Indian J Psychiatry. 2000 Jul;42(3):275-9.

Abstract

The investigation was conducted to find out whether there is any association between delusional disorder and HLA antigens. The sample comprised 50 patients with delusional disorder and 282 control samples collected from normal controls. Statistical analysis revealed that the frequency of A3 antigen of the locus A are significantly higher. In case of HLA - B locus significantly higher frequency of B5 and B21 antigens have also been observed. The present study shows that there may be some association of HLA class-1 antigens with delusional disorder.

摘要

本研究旨在探讨妄想障碍与人类白细胞抗原(HLA)抗原之间是否存在关联。研究对象包括 50 例妄想障碍患者和 282 例来自正常对照组的样本。统计分析显示,A 位点 A3 抗原的出现频率显著升高。而在 HLA-B 位点,B5 和 B21 抗原的出现频率也显著升高。本研究表明,HLA Ⅰ类抗原与妄想障碍可能存在一定的关联。

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本文引用的文献

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Serum HLA typing.血清人类白细胞抗原分型
Tissue Antigens. 1981 Feb;17(2):129-35. doi: 10.1111/j.1399-0039.1981.tb00677.x.
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The molecular genetics of schizophrenia: an overview and forward view.
Eur Arch Psychiatry Clin Neurosci. 1991;240(3):169-73. doi: 10.1007/BF02190759.

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