大动脉炎中的HLA - B5和B21抗原

HLA-B5 and B21 antigens in aortoarteritis.

作者信息

Rose S, Mehra N K, Kumar R, Vaidya M C

机构信息

Department of Anatomy, All India Institute of Medical Sciences, New Delhi.

出版信息

Indian J Pediatr. 1991 Jan-Feb;58(1):85-9. doi: 10.1007/BF02810418.

DOI:10.1007/BF02810418

PMID:1937634

Abstract

The distribution of class I HLA antigens (HLA-A, B) were determined in 50 patients of Aortoarteritis in an Indian population. This included 29 females and 21 males. The difference in antigen frequency was observed between patients and controls with reference to HLA-A19, B5 and B21 antigens. A decreased frequency of HLA-A19 was observed in the patients as compared to controls (14% vs 33.25%, X2 = 6.81, P less than 0.025). Of the B locus antigens, an increased frequency of HLA B5 was observed in the patients as compared to controls (48% vs 29.5%, X2 = 6.2, P less than 0.025). HLA-B21 was also increased in the patients as compared to the controls (18% vs 6.5%, X2 = 6.67, P less than 0.025). These data suggest the involvement of genetic factor (s) in the aetiopathogenesis of this disease. Further, the observations indicate that HLA-B5 and B21 may be associated with Aortoarteritis.

摘要

在印度人群的50例大动脉炎患者中测定了I类HLA抗原（HLA - A、B）的分布情况。其中包括29名女性和21名男性。在患者与对照之间观察到HLA - A19、B5和B21抗原的抗原频率存在差异。与对照相比，患者中HLA - A19的频率降低（14%对33.25%，X² = 6.81，P＜0.025）。在B位点抗原中，与对照相比，患者中HLA B5的频率升高（48%对29.5%，X² = 6.2，P＜0.025）。与对照相比，患者中HLA - B21也升高（18%对6.5%，X² = 6.67，P＜0.025）。这些数据提示遗传因素参与了本病的发病机制。此外，观察结果表明HLA - B5和B21可能与大动脉炎相关。