BIJOY PRATIM CHAUDHURI, MBBS., Post Graduate Student, Department of Psychiatry, Gauhati Medical College & Hospital, Guwahati Ziakur House. R.K. Chaudhun Road, Bharalumukh, Guwahati-781 009.
Indian J Psychiatry. 2000 Jul;42(3):280-90.
The mechanism of action of a relatively new antipsychotic drug-Risperidone differs from conventional antipsychotics like Haloperidol. We compared low dosages of Risperidone with near equivalent dosages of Haloperidol in first episode drug naive Acute and Transient Psychotic disorder. A single blind randomised four-week study protocol was employed. Highly significant and comparable efficacy as assessed by Brief Psychiatric Rating Scale and Global Assessment of Functioning Scale was seen at the end of the Study protocol in both the groups. Risperidone had significantly, an early onset of action on some of the positive as well as negative symptoms with less incidence of Extrapyramidal Symptoms in comparison to Haloperidol. We conclude that Risperidone may represent a potential useful first line agent in the treatment of Acute and Transient Psychotic Disorder.
一种相对较新的抗精神病药物——利培酮的作用机制不同于氟哌啶醇等传统抗精神病药物。我们比较了利培酮的低剂量与氟哌啶醇的近似等效剂量，用于治疗首发、药物未致敏的急性和短暂性精神病性障碍。采用了单盲随机四星期研究方案。在研究方案结束时，两组的简明精神病评定量表和总体功能评定量表评估都显示出高度显著和可比的疗效。与氟哌啶醇相比，利培酮在一些阳性和阴性症状上具有明显更早的起效作用，且锥体外系症状的发生率更低。我们的结论是，利培酮可能是治疗急性和短暂性精神病性障碍的一种潜在有用的一线药物。
