锂对印度受试者肾小球滤过率的长期影响-一项横断面研究。
Long term effects of lithium on glomerular filtration rate in Indian subjects - a cross sectional study.
机构信息
BALJINDER SINGH, PhD., Assistant Professor, Department of Nuclear Medicine, PGlMER, Chandigarh -160012.
出版信息
Indian J Psychiatry. 2000 Oct;42(4):410-4.
Glomerular filtration rate (GFR) was evaluated in thirty patients on lithium and in thirty healthy prospective kidney donors by single compartment, multiple sample plasma clearance method using (99m)Technetium diethylene triamine pentaacetic acid ((99m)TC-DTPA). Normality test revealed that dose and treatment duration were skewed and the coefficient of skewness were 0.067 (p< 0.0001) and 1.41 (p< 0.0001) respectively. Age was marginally skewed (p =0.04) for the control group. At 5% significance level, dose and creatinine were negatively correlated (r=-0.030), whereas age and duration were positively correlated (r =+ 0.53) (single tailed only). Duration and GFR seems to be negatively correlated (r = -0.23), however this correlation did not reach statistically significance level. In the present cross sectional study no significant difference in mean GFR was observed in lithium treated affective disorder patients when compared with the age matched normal subjects.
肾小球滤过率（GFR）评估了 30 例锂治疗患者和 30 例健康前瞻性肾脏供体者，采用单室、多样本血浆清除法，使用（99m）锝二乙三胺五乙酸（（99m）TC-DTPA）。正态性检验显示，剂量和治疗持续时间呈偏态分布，偏度系数分别为 0.067（p<0.0001）和 1.41（p<0.0001）。对照组的年龄呈轻度偏态分布（p=0.04）。在 5%的显著性水平下，剂量和肌酐呈负相关（r=-0.030），而年龄和持续时间呈正相关（r=+0.53）（仅单尾）。持续时间和 GFR 似乎呈负相关（r=-0.23），但这种相关性没有达到统计学意义。在本横断面研究中，与年龄匹配的正常受试者相比，锂治疗情感障碍患者的平均 GFR 没有显著差异。
Zotero 插件