Brown Alistair Graham, Shi Yubing, Arndt Andreas, Müller Jörg, Lawford Patricia, Hose David Rodney
Group of Medical Physics, School of Medicine and Biomedical Sciences, The Royal Hallamshire Hospital, University of Sheffield, Room I108, Beech Hill Road, Sheffield S10 2RX, UK.
Comput Methods Biomech Biomed Engin. 2012;15(6):669-80. doi: 10.1080/10255842.2011.556628. Epub 2011 May 24.
Left ventricular assist devices (LVADs) are carefully designed, but the significance of the implantation configuration and interaction with the vasculature is complex and not fully determined. The present study employs computational fluid dynamics to investigate the importance of applying a realistic LVAD profile when evaluating assisted aortic flow fields and subsequently compares a number of potential anastomosis locations in a patient-specific aortic geometry. The outflow profile of the Berlin Heart INCOR® device was provided by Berlin Heart GmbH (Berlin, Germany) and the cannula was attached at a number of locations on the aorta. Simulations were conducted to compare a flat profile against the real LVAD profile. The results illustrate the importance of applying an LVAD profile. It not only affects the magnitude and distribution of oscillatory shear index, but also the distribution of flow to the great arteries. The ascending aorta was identified as the optimal location for the anastomosis.
左心室辅助装置（LVADs）经过精心设计，但其植入构型以及与脉管系统的相互作用的意义复杂且尚未完全明确。本研究采用计算流体动力学来探究在评估辅助主动脉流场时应用逼真的LVAD轮廓的重要性，并随后在特定患者的主动脉几何形状中比较多个潜在的吻合位置。柏林心脏INCOR®装置的流出轮廓由德国柏林的柏林心脏有限公司提供，插管连接在主动脉的多个位置。进行模拟以比较扁平轮廓与真实LVAD轮廓。结果说明了应用LVAD轮廓的重要性。它不仅影响振荡剪切指数的大小和分布，还影响流向大动脉的血流分布。升主动脉被确定为吻合的最佳位置。
