Khaliq Farah, Alam Kaushal Kumar, Vaney Neelam, Singh T B
Department of Physiology, University College of Medical Sciences & GTB Hospital, Dilshad Garden, Delhi.
Indian J Physiol Pharmacol. 2010 Jul-Sep;54(3):255-64.
The present study aims to evaluate the auditory sensory process in the brainstem, thalamocortical and cortical areas by using auditory evoked potentials [auditory brainstem response (ABR), mid latency response (MLR) and slow vertex response (SVR)], cognitive functions by P300 and motor response by reaction time in children with poor academic performance. Thirty children between 6-12 years of age were selected as subjects on the basis of poor academic school records. While thirty children with good academic performance served as controls. The recordings were done using a computerized evoked potential recorder by 10-20 electrode placement system. There was no difference in the anthropometric parameters and IQ of the two groups. There was a significant increase in latency of waves II, III, IV and V, and Inter-peak latency I-V of ABR in poor performer females. All the component waves of MLR and SVR showed increased latency in the subjects but could not reach the level of significance. There was a significant increase in latencies of P300 at Cz and Pz electrode positions with no change in amplitude in poor performer females. The reaction time was also increased in the poor performer females as compared to the controls. The latencies of all the waves of ABR, P300 and reaction time are also increased in male poor performers as compared to male controls but could not reach the level of significance. The conduction of impulses is slower in pontine and midbrain auditory pathway along with inefficient cortical processing of task relevant stimuli and motor response in female children having poor academic performance.
本研究旨在通过使用听觉诱发电位[听觉脑干反应（ABR）、中潜伏期反应（MLR）和慢顶点反应（SVR）]评估脑干、丘脑皮质和皮质区域的听觉感觉过程，通过P300评估认知功能，并通过反应时间评估学习成绩差的儿童的运动反应。根据学业成绩差的记录，选择30名6至12岁的儿童作为研究对象。同时，30名学业成绩好的儿童作为对照组。使用计算机化诱发电位记录仪，通过10-20电极放置系统进行记录。两组的人体测量参数和智商没有差异。学习成绩差的女性中，ABR的波II、III、IV和V的潜伏期以及峰间潜伏期I-V显著增加。MLR和SVR的所有成分波在研究对象中潜伏期均增加，但未达到显著水平。学习成绩差的女性在Cz和Pz电极位置的P300潜伏期显著增加，波幅无变化。与对照组相比，学习成绩差的女性的反应时间也增加。与男性对照组相比，学习成绩差的男性中ABR的所有波潜伏期、P300潜伏期和反应时间也增加，但未达到显著水平。学习成绩差的女童脑桥和中脑听觉通路的冲动传导较慢，同时对与任务相关的刺激和运动反应的皮质处理效率低下。
