Global Neuroscience Initiative Foundation, Los Angeles, CA, USA.
Nutr J. 2013 Aug 8;12:114. doi: 10.1186/1475-2891-12-114.
The incidence of obesity has increased dramatically over the past several years, and in parallel, so has the prevalence of type 2 diabetes (T2D). Numerous studies have demonstrated that both obesity and T2D are associated with lower cognitive performance, cognitive decline, and dementia. Intake of dietary fructose has also increased. In fact, high-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Given the increase in the incidence of Alzheimer's disease (AD), characterized by an age-related decline in memory and cognitive functioning, in this report we review the effects of obesity on cognitive performance and the impact of high fructose intake in promoting cognitive decline. The paper then considers the effects of omega-3 fatty acids (FAs), which have been linked to promising results in cognitive function including ameliorating the impact of a high-fructose diet.
近年来，肥胖的发病率急剧上升，与此同时，2 型糖尿病（T2D）的患病率也在上升。许多研究表明，肥胖和 T2D 都与较低的认知表现、认知能力下降和痴呆有关。饮食中果糖的摄入量也有所增加。事实上，高果糖玉米糖浆（HFCS）在美国使用的卡路里甜味剂中占了多达 40%。鉴于阿尔茨海默病（AD）的发病率增加，其特征是与年龄相关的记忆和认知功能下降，在本报告中，我们回顾了肥胖对认知表现的影响，以及高果糖摄入对促进认知能力下降的影响。然后，本文考虑了ω-3 脂肪酸（FA）的影响，这些脂肪酸与认知功能的良好结果有关，包括改善高果糖饮食的影响。
