De Wever O, Lapeire L, De Boeck A, Hendrix A
Laboratory of Experimental Cancer Research, Ghent University Hospital, De Pintelaan, 185-B 9000 Gent.
Verh K Acad Geneeskd Belg. 2010;72(5-6):309-26.
Cancer malignancy is characterized by cancer cell invasion within local and distant ecosystems. Data from our laboratory are reviewed with a focus on cross-signaling between cancer cells and host cells such as myofibroblasts, mesenchymal stem cells and adipocytes. Invasion-associated cellular activities, namely epithelial to mesenchymal transition, homotypic and heterotypic cell-cell adhesion, cell-matrix adhesion, migration, proteolysis and vesicle exocytosis, depend on branching networks of signal transduction pathways including activation of trimeric G proteins, phosphoinositide 3-kinase, src, signal transducer and activator of transcription and the Rab, Rac and Rho family of small GTPases. The role of proteolysis in invasion is not limited to breakdown of extracellular matrix but also causes cleavage of pro-angiogenic fragments from cell surface glycoproteins. Some cell types or molecules implicated in invasion-associated activities may serve as prognostic biomarker or as target for patient-tailored therapy.
癌症恶性肿瘤的特征在于癌细胞在局部和远处生态系统中的侵袭。本文回顾了我们实验室的数据，重点关注癌细胞与宿主细胞（如肌成纤维细胞、间充质干细胞和脂肪细胞）之间的交叉信号传导。与侵袭相关的细胞活动，即上皮-间质转化、同型和异型细胞间粘附、细胞-基质粘附、迁移、蛋白水解和囊泡胞吐作用，取决于信号转导途径的分支网络，包括三聚体G蛋白、磷酸肌醇3-激酶、src、信号转导子和转录激活子以及小GTP酶的Rab、Rac和Rho家族的激活。蛋白水解在侵袭中的作用不仅限于细胞外基质的分解，还会导致细胞表面糖蛋白的促血管生成片段的裂解。一些与侵袭相关活动有关的细胞类型或分子可能作为预后生物标志物或作为患者定制治疗的靶点。
