Lipid Research Unit, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Avda. Reyes Católicos, 2, 28040 Madrid, Spain.
Atherosclerosis. 2011 Jun;216(2):467-70. doi: 10.1016/j.atherosclerosis.2011.02.031. Epub 2011 Feb 24.
Adiponectin is an adipose tissue-derived adipocytokine which appears in decreased concentrations in obese patients and in several processes related to cardiovascular disease, such as type 2 diabetes or metabolic syndrome. The aim of this study was to analyze the relationship between adiponectin and components of metabolic syndrome (lipid profile, blood pressure, insulin and insulin resistance) in pubertal Spanish children.
The population-based sample included 810 healthy children (382 boys and 428 girls) 12-16 years of age. Anthropometric parameters and blood pressure were measured. Lipid levels were determined by standard methods, and insulin and adiponectin concentrations were measured by ELISA. Insulin resistance index was assessed by HOMA-IR.
Adiponectin levels were negatively correlated with insulin and HOMA in both boys and girls, and remained significant after adjustment for BMI z-score in girls. After this adjustment, adiponectin maintained a positive correlation with HDL-cholesterol and HDL-phospholipids in both genders, and correlated with triglycerides in girls. Multiple linear regression analysis showed that, after adjustment for BMI z-score, adiponectin accounted for 15.8% of the variation of HDL-cholesterol in girls and for 5% of its variation in boys; meanwhile, it accounted for 15.8% and 12.7% of the variation of HDL-phospholipids in girls and boys, respectively.
Adiponectin levels in 12- to 16-year-old children appear to be more strongly related to better lipid profile and insulin sensitivity in girls than in boys. Our study shows, for the first time to our knowledge, a significant positive correlation between adiponectin and HDL-phospholipids in pubertal children.
脂联素是一种脂肪组织来源的脂肪细胞因子，在肥胖患者和与心血管疾病相关的多种过程中，如 2 型糖尿病或代谢综合征，其浓度会降低。本研究旨在分析青春期西班牙儿童脂联素与代谢综合征成分（血脂谱、血压、胰岛素和胰岛素抵抗）之间的关系。
该基于人群的样本包括 810 名健康儿童（382 名男孩和 428 名女孩），年龄为 12-16 岁。测量了人体测量参数和血压。用标准方法测定血脂水平，用 ELISA 测定胰岛素和脂联素浓度。用 HOMA-IR 评估胰岛素抵抗指数。
在男孩和女孩中，脂联素水平与胰岛素和 HOMA 呈负相关，在女孩中，调整 BMI z 评分后仍有显著相关性。在进行这种调整后，脂联素在两性中均与高密度脂蛋白胆固醇和高密度脂蛋白磷脂呈正相关，在女孩中与甘油三酯呈正相关。多元线性回归分析显示，在调整 BMI z 评分后，脂联素占女孩高密度脂蛋白胆固醇变异的 15.8%，占男孩的 5%；同时，它占女孩和男孩高密度脂蛋白磷脂变异的 15.8%和 12.7%。
12-16 岁儿童的脂联素水平与女孩的血脂谱和胰岛素敏感性的相关性似乎比男孩更强。我们的研究首次表明，在青春期儿童中，脂联素与高密度脂蛋白磷脂之间存在显著的正相关。
