LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
Alzheimers Dement. 2011 Mar;7(2):171-4. doi: 10.1016/j.jalz.2010.06.007.
Hippocampal atrophy is a marker of disease state and progression in Alzheimer's disease. The gold standard to measure hippocampal volume is through manual segmentation. A number of protocols to measure hippocampal volume through manual segmentation have been developed, but the marked heterogeneity of anatomical landmarks has given rise to wide variability of volume estimates. With the aim of fostering the use of hippocampal volume in routine clinical settings, an international task force is currently working on developing a harmonized protocol that will resolve and reduce the present heterogeneity. The task force will then validate the harmonized protocol, develop harmonized probabilistic hippocampal maps, and develop illustrative and educational material on the use of the harmonized protocol and maps.
海马体萎缩是阿尔茨海默病疾病状态和进展的标志物。测量海马体体积的金标准是通过手动分割。已经开发了许多通过手动分割来测量海马体体积的方案，但解剖标志的明显异质性导致了体积估计的广泛变异性。为了促进海马体体积在常规临床环境中的应用，一个国际工作组目前正在努力制定一个协调的方案，以解决和减少目前的异质性。该工作组将随后验证协调方案，开发协调的概率海马体图谱，并制定关于使用协调方案和图谱的说明和教育材料。
