Matsui I, Otani S, Morisawa S
Biochim Biophys Acta. 1978 Dec 1;544(2):372-80. doi: 10.1016/0304-4165(78)90105-8.
The effect of urethan on the induction of ornithine decarboxylase in the early stage of the regeneration of rat liver was studied. The induced activity of ornithine decarboxylase was suppressed by administration of urethan immediately after partial hepatectomy. Although ornithine decarboxylase was induced biphasically by partial hepatectomy, a single intraperitoneal injection of urethan resulted in the reduction of both phases. However, the ornithine decarboxylase activity induced by glucocorticoids and growth hormone was not suppressed by urethan. The increased level of 3',5'-cyclic adenosine monophosphate induced by partial hepatectomy was also reduced by urethan and this suppression was proportional to the suppression of ornithine decarboxylase activity. Reversal of the urethan-induced suppression of ornithine decarboxylase by administration of dibutyryl 3',5'-cyclic adenosine monophosphate was also observed.
研究了氨基甲酸乙酯对大鼠肝脏再生早期鸟氨酸脱羧酶诱导的影响。部分肝切除术后立即给予氨基甲酸乙酯可抑制鸟氨酸脱羧酶的诱导活性。尽管部分肝切除术双相诱导鸟氨酸脱羧酶，但单次腹腔注射氨基甲酸乙酯会导致两个阶段的降低。然而，糖皮质激素和生长激素诱导的鸟氨酸脱羧酶活性不受氨基甲酸乙酯抑制。部分肝切除术诱导的3',5'-环磷酸腺苷水平升高也被氨基甲酸乙酯降低，这种抑制与鸟氨酸脱羧酶活性的抑制成正比。还观察到通过给予二丁酰3',5'-环磷酸腺苷可逆转氨基甲酸乙酯诱导的鸟氨酸脱羧酶抑制作用。
