Academic Unit of Psychological Medicine, Australian National University Medical School, College of Medicine, Biology and Environment, Canberra Hospital, Canberra, Australia.
Indian J Psychiatry. 2009 Jan;51 Suppl 1(Suppl1):S35-8.
Diabetes mellitus is a complex disease with many potential complications. Whilst there have been inconsistent results in regard to an association between cognition and type 2 diabetes, there is evidence that verbal memory and processing speed are the cognitive domains usually impaired. In elderly diabetic subjects, other cognitive domains may also be involved, due to ageing. Glycemic control is implicated in the development of cognitive dysfunction, although more research is needed in this area. Insulin dysregulation and hyperglycemia play an important role in neurodegeneration. Using structural neuroimaging, it has been shown that brain atrophy is an important feature in those with type 2 diabetes. Integrative research is needed using behavioral, cognitive, imaging, and genetic platforms.
糖尿病是一种复杂的疾病，有许多潜在的并发症。虽然关于认知功能与 2 型糖尿病之间的关系存在不一致的结果，但有证据表明，语言记忆和处理速度是通常受损的认知领域。在老年糖尿病患者中，由于年龄的原因，其他认知领域也可能受到影响。血糖控制与认知功能障碍的发展有关，尽管这方面还需要更多的研究。胰岛素失调和高血糖在神经退行性变中起着重要作用。使用结构神经影像学，已经表明脑萎缩是 2 型糖尿病患者的一个重要特征。需要使用行为、认知、影像和遗传平台进行综合研究。
