人体关节软骨的交叉弛豫成像。
Cross-relaxation imaging of human articular cartilage.
机构信息
Department of Electrical Engineering, Magnetic Resonance Systems Research Laboratory, Stanford University, Stanford, California 94305-9510, USA.
出版信息
Magn Reson Med. 2011 Sep;66(3):725-34. doi: 10.1002/mrm.22865. Epub 2011 Mar 17.
Abstract
In this article, cross-relaxation imaging is applied to human ex vivo knee cartilage, and correlations of the cross-relaxation imaging parameters with macromolecular content in articular cartilage are reported. We show that, unlike the more commonly used magnetization transfer ratio, the bound pool fraction, the cross-relaxation rate (k) and the longitudinal relaxation time (T(1)) vary with depth and can therefore provide insight into the differences between the top and bottom layers of articular cartilage. Our cross-relaxation imaging model is more sensitive to macromolecular content in the top layers of cartilage, with bound pool fraction showing moderate correlations with proteoglycan content, and k and T(1) exhibiting moderate correlations with collagen.
摘要
在本文中，我们将交叉弛豫成像应用于人体离体膝关节软骨，并报告了交叉弛豫成像参数与关节软骨中大分子含量的相关性。我们发现，与更常用的磁化传递率不同，结合池分数、交叉弛豫率(k)和纵向弛豫时间(T1)随深度而变化，因此可以深入了解关节软骨顶层和底层之间的差异。我们的交叉弛豫成像模型对软骨顶层的大分子含量更为敏感，其中结合池分数与蛋白聚糖含量具有中度相关性，而 k 和 T1 与胶原具有中度相关性。
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