与预防放射性口干相关的功能结局：口服毛果芸香碱与颌下腺转移。
Functional outcomes related to the prevention of radiation-induced xerostomia: oral pilocarpine versus submandibular salivary gland transfer.
机构信息
Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.
出版信息
Head Neck. 2012 Feb;34(2):168-74. doi: 10.1002/hed.21682. Epub 2011 Mar 17.
BACKGROUND
Xerostomia has a devastating impact on oral function and quality of life in patients who receive radiation treatment for head and neck cancer. The purpose of this study was to examine functional outcomes related to 2 saliva-sparing treatments: (1) oral pilocarpine during radiotherapy; or (2) the submandibular salivary gland transfer (SGT) before radiotherapy.
METHODS
Sixty-nine patients were recruited (SGT = 36; pilocarpine = 33). Speech intelligibility, swallowing outcomes, and quality of life were assessed at 4 points in time (pretreatment, and 1 month, 6 months, and 12 months after the pretreatment assessment).
RESULTS
There were no differences between groups in speech outcomes; however, significant between-group differences existed in swallowing and quality of life outcomes. In all cases, patients who received the SGT procedure had better swallowing outcomes and quality of life scores than the patients who received oral pilocarpine.
CONCLUSION
The SGT should be the treatment of choice between the 2 treatments offered to prevent xerostomia in the present study.
背景
口干症对头颈部癌症放疗患者的口腔功能和生活质量有毁灭性的影响。本研究旨在研究与两种唾液保存治疗相关的功能结果：（1）放疗期间口服毛果芸香碱；或（2）放疗前颌下腺转移（SGT）。
方法
招募了 69 名患者（SGT = 36；毛果芸香碱 = 33）。在 4 个时间点（治疗前和治疗前评估后 1 个月、6 个月和 12 个月）评估言语清晰度、吞咽结果和生活质量。
结果
两组间的言语结果无差异；然而，在吞咽和生活质量结果方面存在显著的组间差异。在所有情况下，接受 SGT 手术的患者的吞咽结果和生活质量评分均优于接受口服毛果芸香碱的患者。
结论
在本研究中，为预防口干症，SGT 应作为两种治疗方法中的首选。
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