Ratnikova L A, Chistiakov V V, Iaguzhinskiĭ L S
Biokhimiia. 1978 Oct;43(10):1809-15.
A regulation mechanism of the interaction of microsomal oxidases and mitochondrial respiratory chain with oxidase substrates is suggested. Quantitative comparison of their affinity to microsomal oxidases and mitochondrial NADH-dehydrogenase is carried out. The interaction with both systems is found to be hydrophobic. It is found that microsomal oxidase substrates inhibit mitochondrial NADH-dehydrogenase at concentrations, which should completely fill the active site of cytochrome P-450. It is suggested that redistribution of reduced equivalents from mitochondria to microsomes and the acceleration of xenobiotic detoxication take place.
提出了微粒体氧化酶和线粒体呼吸链与氧化酶底物相互作用的调节机制。对它们与微粒体氧化酶和线粒体NADH脱氢酶的亲和力进行了定量比较。发现与这两个系统的相互作用都是疏水性的。研究发现，微粒体氧化酶底物在应该完全填满细胞色素P-450活性位点的浓度下抑制线粒体NADH脱氢酶。有人提出，还原当量会从线粒体重新分布到微粒体，从而加速外源性物质的解毒过程。
