Zunich K M, Lane H C
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
J Am Acad Dermatol. 1990 Jun;22(6 Pt 2):1202-5. doi: 10.1016/0190-9622(90)70163-c.
A variety of immunologic abnormalities have been reported in patients with human immunodeficiency virus (HIV) infection. The most characteristic is a decrease in the number and function of CD4 helper/inducer T lymphocytes. Patients with HIV infection also have abnormalities in the number and activity of CD8 suppressor/cytotoxic T lymphocytes, defective soluble antigen recognition, polyclonal B cell activation, and decreased cytotoxicity. The CD4 cell defect is the most critical abnormality in the immunopathogenesis of HIV disease. Understanding the relationship of this defect to the appearance of clinical problems can contribute to the management of patients with HIV infection.
据报道，人类免疫缺陷病毒（HIV）感染患者存在多种免疫异常。最典型的是CD4辅助/诱导性T淋巴细胞数量和功能下降。HIV感染患者的CD8抑制/细胞毒性T淋巴细胞数量和活性也存在异常，可溶性抗原识别缺陷，B细胞多克隆激活，细胞毒性降低。CD4细胞缺陷是HIV疾病免疫发病机制中最关键的异常。了解这一缺陷与临床问题出现之间的关系有助于对HIV感染患者进行管理。
