Zajdela F, Latarjet R
Bull Cancer. 1978;65(3):305-13.
A short review of pathogenic factors in U.V. light skin carcinogenesis in the mouse is presented. Caffeine and theophylline applied locally during U.V. irradiation caused a 50 percent reduction of skin tumour induction in Swiss mice. These two chemicals are inhibitors of DNA postreplication repair, but they also raise the intracellular level of cyclic AMP by inhibiting cAMP phosphodiesterase with, as a consequence, a possible slowing down of cellular growth. Control experiments using three different chemicals capable of raising the cAMP level in epidermal cells gave negative results. These experimental data are compatible with our original hypothesis according to which production of skin cancers by U.V. radiation is in same way related to DNA repair which helps the cell to survive but allows or favours the occurrence of errors in cellular DNA.
本文对小鼠紫外线诱导皮肤癌发生的致病因素进行了简要综述。在紫外线照射期间局部应用咖啡因和茶碱，可使瑞士小鼠的皮肤肿瘤诱导率降低50%。这两种化学物质是DNA复制后修复的抑制剂，但它们也通过抑制环磷酸腺苷磷酸二酯酶来提高细胞内环磷酸腺苷的水平，从而可能减缓细胞生长。使用三种能够提高表皮细胞内环磷酸腺苷水平的不同化学物质进行的对照实验得出了阴性结果。这些实验数据与我们最初的假设相符，根据该假设，紫外线辐射导致皮肤癌的产生与DNA修复以相同方式相关，DNA修复有助于细胞存活，但允许或促进细胞DNA中出现错误。
